Schisandra chinensis berries - Organic Changbai Wu Wei Zi
A randomized, double-blind, placebo-controlled trial in 36 women (ages 40–70) found a standardized Schisandra chinensis extract (BMO-30) significantly reduced menopausal symptoms — particularly hot flushes, sweating, and heart palpitations — measured via the Kupperman Index, over a 12-week follow-up. Citation: Park JY, Kim KH. "A randomized, double-blind, placebo-controlled trial of Schisandra chinensis for menopausal symptoms." [Climacteric. 2016 Dec;19(6):574-580] Link: https://pubmed.ncbi.nlm.nih.gov/27763802/
A second RCT in postmenopausal women examined Schisandra's effect on quadriceps muscle strength and lactate/fatigue markers. Citation: Effect of Schisandra chinensis Extract Supplementation on Quadriceps Muscle Strength and Fatigue in Adult Women: A Randomized, Double-Blind, Placebo-Controlled Trial. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177795/
A systematic review and preclinical meta-analysis (54 animal studies) supports Schisandra's hepatoprotective and anti-inflammatory mechanisms, though this portion of the evidence is animal-only. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358260/
Cistanche - Rou Cong-Rong
Cistanche species, known as Rou Cong-Rong in Chinese, are an endangered wild species and are mainly distributed in the arid lands and warm deserts of northwestern China. Within Traditional Chinese Medicine (TCM), Herba Cistanche is applied as a tonic and/or in a formula for chronic renal disease, impotence, female infertility, morbid leucorrhea, profuse metrorrhagia, and senile constipation. The chemical constituents of Herba Cistanche mainly consist of volatile oils, non-volatile phenylethanoid glycosides (PhGs), iridoids, lignans, alditols, oligosaccharides, and polysaccharides. There have been an increasing number of studies focusing on its bio-activities, including antioxidation, neuroprotection, and antiaging. The objective of this review was to introduce this herb, Cistanche to the world. Its taxonomy, distribution, and corresponding biological functions and molecular mechanisms are addressed in this review.to the world. Its taxonomy, distribution, and corresponding biological functions and molecular mechanisms are addressed in this review.
[Front. Pharmacol., 29 February 2016 Sec. Ethnopharmacology Volume 7 - 2016 | https://doi.org/10.3389/fphar.2016.00041] Herba Cistanche (Rou Cong-Rong): One of the Best Pharmaceutical Gifts of Traditional Chinese Medicine.
Lu Róng, velvet antler (VA)
Lu Róng, is a traditional Chinese medicine, which is used as a food supplement and therapeutic drug in China, Japan, Russia, New Zealand and Southeast Asia. The regenerative characteristics of VA have resulted in great research interest, particularly regarding the fields of organ grafting and stem cell differentiation. Various VA proteomic studies verified that proteins act as the primary bioactive components of VA. The present study aimed to investigate if VA proteins (VApro) influence endothelial progenitor cell (EPC) viability. Various methods have previously been used to investigate VApro, including freezedrying technology, ultrasonic wave methods, high-performance liquid chromatographymass spectrometry, EPCs extraction and culture. Results demonstrated that VApro promoted EPCs proliferation and migration, particularly at a concentration of 1 mg/ml. Furthermore, VApro increased the activation level of Notch1 intracellular domain and Hes1, and the level of phosphorylatedAkt and phosphorylatedmechanistic target of rapamycin. VApro may therefore affect EPC viability via regulation of the Notch and Akt signaling pathways. The present study revealed the effects and potential molecular mechanism of VApro on EPCs, and suggested an association between VA regeneration characteristics and the optimization of EPC viability. These findings may contribute to EPC transplantation research and aid in providing a novel treatment method for vascular diseases in the future. [Mol Med Rep. 2017 Sep;16(3):3161-3168. doi: 10.3892/mmr.2017.7019. Epub 2017 Jul 15. PMID: 28714033 PMCID: PMC5547914] Evaluation of velvet antler total protein effect on bone marrowderived endothelial progenitor cells.
Siraitia grosvenorii - Luo Han Guo
Key findings in the research conducted on Siraitia grosvenorii is a fruit native to China and has many years of medicinal history. Because of its low-calorie and sugar-free properties, it is approved as a sweetener substitute in foods for obese and diabetic patients. Experiments have shown that this sweetener is non-toxic. This article summarises much literature on S. grosvenorii extracts, briefly introduces their chemical composition and metabolic distribution and summarises the possible pharmacological effects of each S. grosvenorii extract. Siraitia grosvenorii extract has anti-diabetic, anti-tumour, anti-inflammatory, antioxidant, neuroprotective and lipogenic inhibitory effects. These pharmacological activities suggest the medicinal value of S. grosvenorii. [Journal of Pharmacy and Pharmacology, Volume 74, Issue 7, July 2022, Pages 953–960, https://doi.org/10.1093/jpp/rgab150 Published: 01 July 2022]. Research progress of pharmacological effects of Siraitia grosvenorii extract.
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